Getting pregnant at an early age means guaranteeing yourself reliable protection against a malignant tumor of the mammary gland, Swiss scientists say. Having a baby up to twenty years halves the risk of breast cancer. Early pregnancy also protects mice. It's all about genetics. Genes that were involved in differentiation and the immune system were highly regulated after pregnancy. At the same time, the activity of coding moments of gene growth decreased.
The activity of a specific Wnt4 gene after pregnancy has also been completely suppressed. The protein of this gene is a feminizing protein. Thus, its absence helps the development of the male fetus. Notch and Wnt are the opposing ingredients of a system that oversees cell fate within the body. When the researchers conducted the Notch analysis, they noticed that the genes for which he is responsible are highly regulated. Notch-stimulating proteins are also highly regulated, Notch-blocking proteins are suppressed.
The signal ratio of Notch / Wnt for a long period changes in the basal cellular material of the mammary gland of rodents during pregnancy. “A decrease in Wnt activity is the opposite of what is seen with many cancers. Therefore, tight control of Notch / Wnt is very likely to insure against uncontrolled tissue growth in cancer, ”said lead scientist Mohamed Bentiers-Alge.
